TOXI0441-1 : Experimental Toxicology

Study Programmes 2015-2016

TOXI0441-1

Experimental Toxicology

Duration :

10h Th

Number of credits :

Master in biomedicine (120 ECTS)		2
Master in biomedicine (120 ECTS)		2

Lecturer :

Language(s) of instruction :

French language

Organisation and examination :

Teaching in the first semester, review in January

Units courses prerequisite and corequisite :

Prerequisite or corequisite units are presented within each program

Course contents :

Use of in vivo and in vitro tests to evaluate toxicity of chemical substances and drugs

Learning outcomes of the course :

To evaluate toxicity of chemical substances and drugs, and before human use, several experimental steps must be done :

micro-organism tests : speed and cheap, but with a lot of disadvantages (cell wall, none micro-oranite, specificity of ADN repair mechansisms, etc...);
eukaryotic cells tests : allow to control exactly the concentration used but not the study of influence of metabolic activation/inactivation (important in the study of cancer);
in vivo tests : results more sensitive and easier to transpose to human; the choice of a species is the "key" choice ; it is determinated by taking into account metabolic process and detoxification mechanisms.

Prerequisite knowledge and skills :

Having had success in "Toxicological precepts" of the former academic year

Planned learning activities and teaching methods :

Not appliable

Mode of delivery (face-to-face ; distance-learning) :

...