BIOC0232-1 : Macromolecular biochemistry

Study Programmes 2015-2016

BIOC0232-1

Macromolecular biochemistry

Duration :

30h Th, 30h Pr

Number of credits :

Master in chemistry (120 ECTS)		4
Master in chemistry (60 ECTS)		4

Lecturer :

Moreno Galleni

Language(s) of instruction :

English language

Organisation and examination :

Teaching in the first semester, examination in June

Units courses prerequisite and corequisite :

Prerequisite or corequisite units are presented within each program

Course contents :

Editer

1) Chemical properties of amino acids and of the polypeptide chain
1.1 Nature of the polypeptide chain
1.2 Amino acids
1.3 Detection of aminoacids, peptides and proteins
1.4 Determination of the protein size
1.5 Determination of the aminoacid sequence
1.6 Chemical synthesis of peptides
1.7 Non ribosomal synthesis of peptides
1.8 Post transcription modification of the polypeptide chain
2) Mechanism of protein localization in prokaryotes and eukaryotes
3) Interactions affecting the properties of proteins
3.1 Nature of non covalent interactions
3.2 Intramolecular interactions
4) Conformational properties of proteins
4.1 Secondary and ternary structures of proteins
4.2 Spectroscopic properties od proteins in solution
5) Biophysical properties of soluble and membranar properties

Learning outcomes of the course :

The course will be devoted to the structural and chemical properties of proteins.

Prerequisite knowledge and skills :

Lectures in general biochemistry
Thermodynamic and classical physic
Organic chemistry

Planned learning activities and teaching methods :

30 h of practical course, dedicated to protein purification and enzyme catalysis

Mode of delivery (face-to-face ; distance-learning) :

15 lessons of 2 hours