Study Programmes 2015-2016
BIOC0210-5  
Functional properties of biological macromolecules
Duration :
20h Th, 10h Mon. WS
Number of credits :
Master in biomedicine (120 ECTS)2
Master in biomedicine (60 ECTS)2
Master in biochemistry and molecular and cell biology (120 ECTS)3
Master in biology (60 ECTS)3
Lecturer :
André Matagne
Language(s) of instruction :
French language
Organisation and examination :
Teaching in the first semester, review in January
Units courses prerequisite and corequisite :
Prerequisite or corequisite units are presented within each program
Course contents :
The main focus of this course is enzymology and it is organized as follows: Chapter 1: General properties of enzymes. Chapter 2: Steady-state kinetics. Chapter 3: Enzyme inhibition. Chapter 4: Effect of pH, temperature, viscosity and other experimental factors. Chapter 5: Reactions of two substrates. Chapter 6: Transient-state kinetics. Chapter 7: Cooperativity and allosteric interactions. Chapter 8: Enzyme inactivators. Chapter 9: Enzyme cofactors. Chapter 10: Mechanism of chymotrypsin. Chapter 11: Basic catalytic principles. Chapter 12: Regulation of catalytic activity. In addition some lectures might be dedicated to specific topics. This year, a lecture on the formation of disulphide bonds in proteins will be given by professor J.-F. Collet, WELBIO and de Duve Institute, U.C.L.
Learning outcomes of the course :
The aim of the course is to make students familiar with enzyme mechanisms and fundamentals of enzyme kinetics. Other topics related to the biological activity of proteins might be covered.
Prerequisite knowledge and skills :
Course on "Chemistry of biological macromolecules" (BAC3 Biology), which includes an introduction to enzyme catalysis (chapters 1-3; note that both theoretical and practical aspects are covered).
Planned learning activities and teaching methods :
Most lectures are given using the blackboard and (hopefuly) white chalk. Problems tutorials are organized in relation with some chapters.
Mode of delivery (face-to-face ; distance-learning) :
Face-to-face only
Recommended or required readings :
Lecture notes will be available following the lectures.
Reference book: A. Cornish-Bowden, Fundamentals of enzyme kinetics, fourth edition, Wiley-Blackwell, 2012.
Assessment methods and criteria :
Written exam
Work placement(s) :
Organizational remarks :
Lectures will be organized according to the schedule known by the students. The professor will inform the students in advance of any possible modification to this
Contacts :
André Matagne, PhD, Professor, Enzymology and Protein Folding, Centre for Protein Engineering, Life Science Department, Institut de Chimie B6c (room 3/1), Allée de la Chimie, 3, University of Liège, B4000 Liège (Sart-Tilman), Tel.: +32 (0)4 3663419, Fax: +32 (0)4 3663396, Email: amatagne@ulg.ac.be