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| TOXI0350-1 | Experimental toxicology (in vitro tests)
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| Duration : | 10h Th |
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| Number of credits : |
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| Lecturer : | Corinne Charlier |
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Language(s) of instruction :
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| French language |
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Organisation and examination :
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| Teaching in the first semester, review in January |
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Course contents :
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| Use of in vivo and in vitro tests to evaluate toxicity of chemical substances and drugs |
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Learning outcomes of the course :
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| To evaluate toxicity of chemical substances and drugs, and before human use, several experimental steps must be done :
- micro-organism tests : speed and cheap, but with a lot of disadvantages (cell wall, none micro-oranite, specificity of ADN repair mechansisms, etc...);
- eukaryotic cells tests : allow to control exactly the concentration used but not the study of influence of metabolic activation/inactivation (important in the study of cancer);
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in vivo tests : results more sensitive and easier to transpose to human; the choice of a species is the "key" choice ; it is determinated by taking into account metabolic process and detoxification mechanisms.
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Prerequisites and co-requisites/ Recommended optional programme components :
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| "Toxicology" 1st master in Pharmaceutical sciences |
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Planned learning activities and teaching methods :
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| ... |
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Mode of delivery (face-to-face ; distance-learning) :
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| 5 sessions of 2 hours, once a week, 1st semester |
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Recommended or required readings :
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| Slides copy |
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Assessment methods and criteria :
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| Oral evaluation |
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Work placement(s) :
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Organizational remarks :
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Contacts :
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| Professeur Corinne CHARLIER
Clinical, Forensic and Environmental Toxicological laboratory
CHU B35
Sart-Tilman, B4000 Liège
Tél.04/3667683
Fax 04/3668889
e-mail : C.Charlier@chu.ulg.ac.be |
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