 | | |
| MICR0004-1 | Complement of microbiology : bacterial pathogenicity
|
|
| Duration : | 15h Th |
|
| Number of credits : |
| Master in Biochemistry and Molecular and Cell Biology, Research Focus, 1st year | | 2 |
|
| Master in Biochemistry and Molecular and Cell Biology, Teaching Focus, 1st year | | 2 |
|
| Master en biochimie et biologie moléculaire et cellulaire, à finalité spécialisée en bio-industrie, 1st year | | 2 |
|
| Master in Biochemistry and Molecular and Cell Biology, Professional Focus in
Industrial Biochemistry, 1st year | | 2 |
|
| Master en biochimie et biologie moléculaire et cellulaire, à finalité spécialisée en bioinformatique et modélisation, 1st year | | 2 |
|
|
|
| Lecturer : | Bernard Joris |
|
Language(s) of instruction :
|
| French language |
|
Organisation and examination :
|
| Teaching in the second semester |
|
Course contents :
|
| SECTION I: Approaches to the study of bacterial pathogenesis
- Microbes and disease: establishing a connection
- Models for studying bacterial pathogenesis
- Strategies for identifying bacterial pathogenicity genes
- Genetics determinants of bacterial pathogenicity
SECTION II: Bacterial adherence: role of adhesins in the context of bacterial pathogenesis
- Fimbrial adhesins: adhesive molecules on a "stalk"
- Non-pilus (non fimbrial) adhesins
- Biofilms: the story of microbial communities
SECTION III: Poisoning the host by toxins
- Toxins damaging cellular membranes: paradigms and molecular features
- Toxins acting on intracellular targets
SECTION IV: Cellular invasion by bacterial pathogens
- Mechanism of bacterial entry into host cells
- The bacterial life in a vacuole
- The bacterial life in the cytosol
SECTION V: Bacterial evasion of host defences
- Bacterial handling of host nutrients: the iron paradigm
- Bacterial escape from the complement system
- Bacterial resistance to antimicrobial peptides
- Bacteria-induced host cell death
SECTION VI : Specific bacterial pathogens
-
Staphylococcus aureus: many types of staphylococcal infection
-
Escherichia coli : lmany types of infecton
-
Streptococcus pneumoniae
- Group A and Group B Streptococcus
-
Pseudomonas aeruginosa
|
|
Learning outcomes of the course :
|
| Successful completion of this course should enable students to:
- demonstrate broad knowledge of the cellular and molecular bases of bacterial host pathogen interactions;
- describe the principal mechanisms by which specific bacterial pathogens infect their hosts and cause disease.
|
|
Prerequisites and co-requisites/ Recommended optional programme components :
|
| Courses of general bacteriology and of bacterial physiology and genetics |
|
Planned learning activities and teaching methods :
|
| |
|
Mode of delivery (face-to-face ; distance-learning) :
|
| Face-to-face |
|
Recommended or required readings :
|
| Reference book
Bacterial Pathogenesis. A molecular approach
Brenda A. Wilson, Abigail A. Salyers and Dixie D. Whitt, Malcom E. Winkler
Third edtion
ISBN 978-1-55581-418-2 |
|
Assessment methods and criteria :
|
| Oral exam |
|
Work placement(s) :
|
| |
|
Organizational remarks :
|
| |
|
Contacts :
|
| Joris Bernardbjoris@ulg.ac.be
Tel: 04 3662954
Secretariat
Julémont Fabienne
04 366 3341 |
|
