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| GENE0004-1 | Molecular biology of the gene
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| Duration : | 60h Th, 30h Pr |
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| Number of credits : |
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| Lecturer : | Franck Dequiedt |
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Language(s) of instruction :
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| French language |
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Organisation and examination :
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| All year long |
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Course contents :
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| - History of Molecular Biology
- The Molecules of Heredity : structure and properties of nucleic acids
- Genes : structure and evolution
- Genomes : Structure, évolution, organization of the genetic material, chromatin and chromosomes
- The RNA world : diversity and functions of RNA
- Proteins : Principles of traduction, adressing and modifications
- Transcription in Prokaryotes : Principles, molecular effectors and regulation
- Chromosome and extra-chromosomal genomes réplication : comparison between eukaryotes and prokaryotes
- Recombination and DNA repair
- Transcription in eukaryotes
- RNA Processing
- Regulation of gene expression in eukaryotes :transcriptional and post-transcriptional regulation |
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Learning outcomes of the course :
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| At the end of this course, the student should have acquired strong knowledge on the structure, synthesis and the use of heredity molécules (DNA and RNA) in replication, repair, transcription and translation. The
molecular effectors governing these processes will be studied. Using basic genomic and mechanistic insights from this course, the student should be able to understand and explain the evolutionnary differences between prokaryotes to eukaryotes. |
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Prerequisites and co-requisites/ Recommended optional programme components :
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| GENE0201-2 (Prerequisite)
BIOC0724-3 (Co-requisite) |
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Planned learning activities and teaching methods :
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| Auditorium (60h Th) and laboratory (30h Pr) |
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Mode of delivery (face-to-face ; distance-learning) :
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| Face-to-face. |
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Recommended or required readings :
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| Students can choose from two reference books : Genes XI by B. Lewin (Ed. Jones & Bartlett, USA) and Molecular biology of the gene, by James Watson and colleagues (Ed Pearson Education). |
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Assessment methods and criteria :
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| Assessment will include a final exam (70%), end of chapter quiz (10%) during the year and practical (20%). |
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Work placement(s) :
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Organizational remarks :
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Contacts :
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| Franck Dequiedt
fdequiedt@ulg.ac.be |
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