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| Version 2013-2014 |
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| CHIM0218-1 | Elements of medicinal chemistry
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| Duration : | 15h Th |
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| Number of credits : |
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| Lecturer : | Bernard Pirotte |
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Language(s) of instruction :
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| French language |
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Course contents :
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| The course reviews the fundamental principles used in drug design. It tries to explain how were found, and how are still selected today, the new chemical entities developed as new therapeutic agents. The course tries to establish a link between the chemical structure of a drug and its biological activity. The following parts are examined : structural modifications of known active substances; structure-activity relationships; definition of a pharmacophore, of a prodrug, concept of bioisosterism, importance of the stereochemistry, drug-receptor interaction. |
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Learning outcomes of the course :
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| The aim of the course is the presentation of the traditional and innovative concepts used in drug design. This course also aims at explaining to the students that the pharmacological and therapeutic activity of a medicinal product is tightly related to its chemical structure. Since most of the drugs found on the market are issued from organic synthesis, this course also allows to demonstrate one of the multiple valorisation possibilities of organic chemistry. |
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Prerequisites and co-requisites/ Recommended optional programme components :
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| Basic knowledge of inorganic and organic chemistry. |
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Planned learning activities and teaching methods :
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| There is no practical work associated to this course. |
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Mode of delivery (face-to-face ; distance-learning) :
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| In accordance with the students, who are usually on a training course during the second semester, the lessons are traditionally given on Friday afternoon, from 14h00 to 15h30 and from 15h45 to 17h15 (february-march) during five weeks. |
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Recommended or required readings :
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| Written notes are distributed to the students during the first lesson. |
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Assessment methods and criteria :
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| A written exam on the theoretical part of the course.
An oral exam consisting of a discussion on a scientific article devoted to medicinal chemistry distributed to the students during the last lesson. |
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Work placement(s) :
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| none |
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Organizational remarks :
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| none |
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Contacts :
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| Bernard PIROTTE, professeur ordinaire
Laboratoire de Chimie Pharmaceutique, Bât. B36, 1, Avenue de l'Hôpital, C.H.U. - Tour 4 - niveau +5 - Sart Tilman, B-4000 Liège
Tél. : + 32/(0)4/366.43.65 - Fax : + 32/(0)4/366.43.62 - e-mail: B.Pirotte@ulg.ac.be |
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