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| ANIM0003-1 | Immunology and immunochemistry
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| Duration : | 12h Th, 12h Pr |
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| Number of credits : |
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| Lecturer : | Daniel Portetelle |
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Language(s) of instruction :
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| French language |
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Organisation and examination :
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| Teaching in the second semester |
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Course contents :
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| . Overview of the immune system: historical perspective, innate immunity, acquired immunity
. Cells and organs of the immune system: hematopoiesis, CD antigens, cells and organs, antigen-presenting cells, dendritic cells, leucocytes migration and homing;
. Generation of B-cell and T-cell responses:
antigens;
immunoglobulins: structure and function;
antigen-antibody interactions; principles and applications; organization and expression of immunoglobulin genes; antibody engeneering;
B-cell maturation activation and differentiation;
major histocompatibility complexes;
antigen processing and presentation;
T-cell receptor, T-cell maturation, activation and differentiation;
Immune effector mechanisms:
cytokines;
. cell-mediated and humoral effector responses; regulation of the immune effector response
. Other aspects of immunity (overview):
immunodeficiency, tolerance, autoimmunity, hypersensitive reactions, inflammations, external factors, vaccinology (for more details, see ANIM0009-A-Immunobiology)
. Practical works:
productions of antibodies, precipitation reactions, agglutination reactions, the complement system and its applications, radioimmunoassay, enzyme-linked immunosorbent assay, overview of other modern techniques. |
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Learning outcomes of the course :
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| Acquisition of the molecular and cellular bases of immunology.
Supply of requisite informations on mechanisms and main current and prospective applications.
After completing the course the student is expected to
- understand the mechanism of the immune system of the being alive
- integrate the immunochemical approach in detection systems of molecules of some importance |
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Prerequisites and co-requisites/ Recommended optional programme components :
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| BIOL2015 - Molecular biology
BIOL2011 - Comparative animal anatomy and physiology |
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Planned learning activities and teaching methods :
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Mode of delivery (face-to-face ; distance-learning) :
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| Lectures : 12h
Practical Works : 12h |
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Recommended or required readings :
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| Kuby Immunology (Owen, Punt, Stranford), 7°ed, 2013, W.H. Freeman, New York, 800 pages
Immunologie: le cours de J.Kuby: french translation of the 7th ed. by C. Friedman, DUNOD, Paris, 2014, 800 pages.
Text notes (PowerPoint) available on line. |
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Assessment methods and criteria :
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| Written examination (100%) |
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Work placement(s) :
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Organizational remarks :
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Contacts :
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| Portetelle, Daniel (Professeur ordinaire - Chef de service)
Microbiologie et Génomique
081 62 23 54
daniel.portetelle@ulg.ac.be |
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| Items online : |
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| Notes on line |
| PowerPoint available on ecampus. |
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