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| Version 2012-2013 |
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| CHIM9265-1 | Introduction to continuous flow organic synthesis
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| Duration : | 15h Th, 10h Pr, 1d Vis. |
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| Number of credits : |
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| Lecturer : | Jean-Christophe Monbaliu |
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Language(s) of instruction :
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| English language |
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Course contents :
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| While batch chemistry has been used to process organic materials for centuries, increasing economic and environmental pressures have stimulated chemists to improve and rethink synthetic approaches and processes. Flow chemistry has emerged over the last few decades as an economically viable alternative to batch for a wide variety of synthetic applications. Besides, flow chemistry provides significant process enhancements as well as appealing opportunities: accurate control of reaction conditions, increased safety, ease for scale-up to larger production, high throughput and access to a wide range of conditions.
This course will benefit to students in chemistry who are interested in pharmaceutical, fine chemical, R&D and manufacturing applications. Fundamental principles and technologies used in the continuous manufacturing of small organic molecules, as well as recent examples from the literature will be thoroughly discussed. Attendees will not only receive an extensive state-of-the-art overview, but will also be given a chance to manipulate equipment and design continuous flow synthetic routes.
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Introduction : Definitions, strategies, opportunities and challenges, equipment (2 h)
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Reaction engineering principles (2 h)
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Selected examples of single step transformations (2 h)
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Selected examples of multi-step transformations (2 h)
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Multi-phase transformations : liquid-liquid, liquid-gas, supported reagents and catalysts (2 h)
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Continuous purification and in-line analysis (2 h)
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Design and scaling of continuous processes (3 h)
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Learning outcomes of the course :
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- Rethink organic synthesis within continuous flow reactors;
- Enhance skills in organic synthesis: more control, more safety, much broader range of reaction conditions;
- Design and optimize multi-step continuous synthesis systems, including purification and in-line analysis;
- Understand basic concepts of reaction engineering;
- Get familiar with process development and intensification, manufacturing strategies.
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Prerequisites and co-requisites/ Recommended optional programme components :
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| Background in Organic Chemistry |
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Planned learning activities and teaching methods :
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Lecture : Delivery of material in a lecture format; includes theoretical background and recent examples from the literature. Slides are available to the students (60%);
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Group work : Participatory learning, lab preparation (10%);
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Labs : Demonstration and experiments (30%);
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Visits : Visit of an industrial facility (to be confirmed).
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Mode of delivery (face-to-face ; distance-learning) :
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Recommended or required readings :
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- Micro Reaction Technology in Organic Synthesis, Charlotte Wiles and Paul Watts, CRC Press, Boca Raton, 2011 (ISBN: 978-1-4398-2471-9);
- Chemical Reactions and Processes under Flow Conditions, Santiago V. Luis and Eduardo Garcia-Verdugo, RSC Green Chemistry Series, 2009 (ISBN: 978-0-85404-192-3);
- Fundamentals of Heat and Mass Transfer (6th Edition), Frank P. Incropera, David P. DeWitt, Theodore L. Bergman and Adrienne S. Lavine, John Wiley & Sons, 2007 (ISBN: 978-0-471-45728-2);
- Fluid Mechanics: Fundamentals and Applications, Yunus A. Çengel and John M. Cimbala (2nd Edition), McGraw-Hill, 2010 (ISBN: 978-0-07-352926-4);
- Recent literature (appropriate references will be delivered to illustrate the lectures).
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Assessment methods and criteria :
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| Oral exam and performance during lab sessions. |
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Work placement(s) :
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Organizational remarks :
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Contacts :
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