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| BIOC0720-1 | Structure of biological macromolecules
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| Duration : | 15h Th, 20h Pr, 5h Mon. WS |
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| Number of credits : |
| Advanced Master in Nanotechnology | | 4 |
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| Master in Biochemistry and Molecular and Cell Biology, Research Focus, 1st year | | 2 |
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| Master in Biochemistry and Molecular and Cell Biology, Teaching Focus, 1st year | | 2 |
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| Master en biochimie et biologie moléculaire et cellulaire, à finalité spécialisée en bio-industrie, 1st year | | 2 |
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| Master in Biochemistry and Molecular and Cell Biology, Professional Focus in
Industrial Biochemistry, 1st year | | 2 |
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| Master en biochimie et biologie moléculaire et cellulaire, à finalité spécialisée en bioinformatique et modélisation, 1st year | | 2 |
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| Master in Biological Sciences | | 2 |
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| Lecturer : | Paulette Charlier |
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Language(s) of instruction :
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| French language |
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Organisation and examination :
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| Teaching in the first semester, review in January |
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Course contents :
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| The different experimental steps that will lead to the image of a biomolecule using the technique of X-ray diffractionby monocrystal will be described. Three examples illustrating the relations structure-function will be approached, on the basis of research articles describing structural analysis of different proteins illustrating the following 3 families: - proteins controlling the DNA transcription, - serine proteases, - membrane proteins. |
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Learning outcomes of the course :
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| This course gives to the future biochemists the bases necessary to understand the principles of determination of 3D structures by X-ray crystallography in order to enable them to make an objective use of the crystallographic models. |
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Prerequisites and co-requisites/ Recommended optional programme components :
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| Course of physics of 1st cycle. Basic knowledge in X-ray crystallography and knowledge of the basic principles of the structures of proteins. |
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Planned learning activities and teaching methods :
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| This lecture will be given in a classical form, including the use of a PowerPoint presentation, a chalk and a black board. |
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Mode of delivery (face-to-face ; distance-learning) :
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Recommended or required readings :
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| CD rom including Lectures powerpoint presentations, research articles, PDB files and tutorials will be available.
Reference books :
- "Crystallography made hook clear: With guide for users for macromolecular models." Scale Rhodos, Academic Press 2000
- "Introduction to Protein Structure" Carl Branden and John Tooze, Garland Publishing 1999 CD roms:
- PS ² and Kinemage Supplement to "Introduction to Protein Structure" Carl Branden and John Tooze, Garland Publishing 1999 |
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Assessment methods and criteria :
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| A written or oral exam will be organized. |
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Work placement(s) :
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Organizational remarks :
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Contacts :
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| Paulette CHARLIER
Institut de Physique, Bât. B5a - 1/41
Sart-Tilman, 4000 Liège
Call 00 32 (0)4/366.36.19
Fax 00 32 (0)4/366.49.54
E-mail : Paulette.Charlier@ulg.ac.be |
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