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| Version 2011-2012 |
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| SBIM0481-1 | Molecular and cellular oncology
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| Duration : | 30h Th, 20h SEM |
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| Number of credits : |
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| Lecturer : | Yvette Habraken, Agnès Noël |
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Language(s) of instruction :
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| French language |
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Course contents :
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| Cancer is the result of permanent modifications in the genome of the cell that is the origin point of a tumor. These modifications (mutations) have to do with cancer genes, oncogenes and tumor-suppressive genes. As a result these cells acquire particular capacities that are responsible for a "cancerous phenotype". Normal version of proteins produced by mutated genes are part of the means of communication that control proliferation, apoptosis, migration ... The course will examine modified pathways and their contribution to cancer growth. Beyond the modifications to the genome of cancerous cells themselves, we also observe in cancers disturbances of the relation between cancerous cells and their environment. These matters will be discussed, as well as tumoral angiogenesis, and models allowing us to study cancers in vivo and in vitro. |
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Learning outcomes of the course :
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| The main objective is to develop the capacity to integrate concepts acquired previously with recent scientific literature in order to understand the cellular and molecular mechanisms underlying the different steps of cancer progression. |
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Prerequisites and co-requisites/ Recommended optional programme components :
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| Molecular BiologyPrinciple of cellular regulation
Complement of cellular regulation |
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Planned learning activities and teaching methods :
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| Based on specific questions, the students will search for information with different tools (articles, books, internet) with the aim to:
- determine parameters defining a cancer cell
- identify signaling pathway deregulated in cancers
- understand the key role played by the tumor microenvironment in cancer progression
- describe the molecular mechanisms of DNA reparation and failures associated with cancer
- appreciate the advantages and limitations of specific experimental models |
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Mode of delivery (face-to-face ; distance-learning) :
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| face-to-face and work in a team |
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Recommended or required readings :
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| Recent up to date scientific articles |
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Assessment methods and criteria :
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| Oral exam |
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Work placement(s) :
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Organizational remarks :
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Contacts :
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| Agnès Noel
Tel 04/366 25 69
Email : agnes.noel@ulg.ac.be
Yvette Habraken
Tel : 04/366 24 47
Email : Yvette.Habraken@ulg.ac.be
Julie Lecomte
Tel : 04/366 22 17
Email : jlecomte@ulg.ac.be |
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