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| SDOC0009-1 | Applications de la spectrométrie de masse en biophysique
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| Duration : | 10h Th |
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| Number of credits : |
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| Lecturer : | Valérie Gabelica |
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Language(s) of instruction :
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| French language |
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Course contents :
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| 1- Introduction to mass spectrometry of biopolymers.
2- Introduction to folding and non-covalent assembly
3- Special mass spectrometry techniques for the biophysical characterization of biopolymers: direct analysis of the complexes, dissociation methods, hydrogen/deuterium exchange and other chemical labeling methods, ion mobility spectrometry, ion spectroscopy.
4- Examples and generalizations in the case of proteins and nucleic acids. |
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Learning outcomes of the course :
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| Understand which techniques is best appropriate to a given problem, what are the limitations of the different methods, what are the underlying assumptions in the data interpretation process. |
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Planned learning activities and teaching methods :
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| The presential lessons require active participation and try to stimulate critical thinking. A bibliography search and its critical analysis will be requested. |
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Mode of delivery (face-to-face ; distance-learning) :
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| About 5 lectures (2h) |
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Recommended or required readings :
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| Copy of the slides. List of key review/tutorial articles. |
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Assessment methods and criteria :
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| Oral presentation of a literature analysis. |
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Contacts :
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| Dr. Valérie Gabelica
Institut de Chimie, Bat B6c, Local R65/A
Tel. +32-4-366.3432
e-mail. v.gabelica@ulg.ac.be |
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