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| GENE0432-3 | Genetic and biochemical aspects of evolution
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| Duration : | 25h Th, 20h Pr |
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| Number of credits : |
| Master in Biochemistry and Molecular and Cell Biology, Research Focus, 1st year | | First semester | | 3 |
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| Master in Biochemistry and Molecular and Cell Biology, Teaching Focus, 1st year | | First semester | | 3 |
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| Master en biochimie et biologie moléculaire et cellulaire, à finalité spécialisée en bio-industrie, 1st year | | First semester | | 3 |
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| Master in Biochemistry and Molecular and Cell Biology, Professional Focus in
Industrial Biochemistry, 1st year | | First semester | | 3 |
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| Master en biochimie et biologie moléculaire et cellulaire, à finalité spécialisée en bioinformatique et modélisation, 1st year | | First semester | | 3 |
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| Master in Biological Sciences | | First semester | | 2 |
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| Lecturer : | Denis Baurain, Moreno Galleni, Claire Remacle |
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| Coordinator : | Claire Remacle |
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Language(s) of instruction :
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| French language |
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Course contents :
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| Genetic aspects of evolution (7.5 h, C. Remacle)
- Genetic factors of evolution (mutation, migration, selection, genetic drift)
- Mechanisms contributing to speciation (species definition, pre- and postzygotic barriers; types of speciation (sympatric, allopatric), from speciation to macroevolution)
Molecular aspects of evolution (10.5 h, D. Baurain)
- Variation in DNA sequences
- Estimating genetic distance
- Evolution and natural selection
- Quantifying natural selection on DNA sequences
- On trees and evolution
- Inferring trees
- Genome evolution
Functional adaption at the biochemical level (7.5 h, M. Galleni)
- Adaptation of proteins to various environmental factors (t°, pH...)
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Learning outcomes of the course :
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| Make students conscious of the importance of evolution. To this end, the course offers three different parts: (1) genetic mechanisms of evolution, (2) molecular consequences of evolution (including computational approaches for molecular evolution), and (3) functional adaptation of proteins (illustrated with concrete situations). |
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Prerequisites and co-requisites/ Recommended optional programme components :
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| Elements of biology, genetics and biochemistry of the Bac level. |
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Mode of delivery (face-to-face ; distance-learning) :
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| First quadrimester course taking usually place in one of the lecture rooms of the Botanical Institute in Sart Tilman (B.22). The sequence of the course is that of the general presentation. |
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Recommended or required readings :
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| Notes and PowerPoint slides for Cl. Remacle. PowerPoint slides and textbook for D. Baurain [Cristianini N and Hahn MW (2007) Introduction to Computational Genomics, Cambridge University Press; chapters 5 to 8]. |
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Assessment methods and criteria :
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| Written examination. One question for the first and last partim of the course, two for the second. Examination is successful if the note is 10/20 and no partim is less than 8/20. |
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Contacts :
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| C. Remacle (c.remacle@ulg.ac.be)
D. Baurain (denis.baurain@ulg.ac.be)
M. Galleni (mgalleni@ulg.ac.be) |
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