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| TOXI0441-1 | Experimental Toxicology
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| Duration : | 10h Th |
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| Credits/ECTS : |
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| Holder(s) : | Corinne Charlier |
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| Language : | French language |
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| Course contents : | Use of in vivo and in vitro tests to evaluate toxicity of chemical substances and drugs |
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| Course objective : | To evaluate toxicity of chemical substances and drugs, and before human use, several experimental steps must be done :
- micro-organism tests : speed and cheap, but with a lot of disadvantages (cell wall, none micro-oranite, specificity of ADN repair mechansisms, etc...);
- eukaryotic cells tests : allow to control exactly the concentration used but not the study of influence of metabolic activation/inactivation (important in the study of cancer);
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in vivo tests : results more sensitive and easier to transpose to human; the choice of a species is the "key" choice ; it is determinated by taking into account metabolic process and detoxification mechanisms.
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| Prerequisites : | Having had success in "Toxicological precepts" of the former academic year |
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| Workshops : | Not appliable |
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| Organization : | ... |
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| Written notes : | ... |
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| Assessment : | Oral evaluation in january |
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| Contacts : | Professeur Corinne CHARLIER
Clinical,Forensic and Environmental Toxicological laboratory
CHU B35
Sart-Tilman, B4000 Liège
Tél.04/3667683
Fax 04/3668889
e-mail : C.Charlier@chu.ulg.ac.be |
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