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| CHIM0332-1 | Medicinal chemistry (Part I)
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| Duration : | 37,5h Th, 40h Pr |
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| Credits/ECTS : |
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| Holder(s) : | Bernard Pirotte |
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| Language : | French language |
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| Course contents : | Introduction to Medicinal Chemistry (15 h) : scope of medicinal chemistry, presentation of several important reactions in organic synthesis, fundamental principles used in drug design, summary of the rules of the I.U.P.A.C. nomenclature.
Systematic Part 1 : drugs used against pathological organisms, anticancer drugs, pesticides, drugs of the central nervous system (partim 1). |
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| Course objective : | Medicinal chemistry is a science devoted to the design, the synthesis and the understanding of the mode of action of drugs, and more specifically, those obtained by organic synthesis. This science tries to establish a link between the chemical structure of a drug and its biological activity.
The general aims of this course are the following : to familiarize the student with the active components of drugs, their chemical structures, their origin, their design, their evolution, the field of their therapeutic applications, their international nonproprietary names and several examples of trade marks. Some examples of synthesis are provided, the general physicochemical properties are reviewed. The systematic part is introduced by the presentation of the traditional and innovative steps in drug design, by the review of classical synthetic processes and by a summary of the I.U.P.A.C. nomenclature. |
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| Prerequisites : | Appropriate knowledge of inorganic and organic chemistry, basic knowledge of physiology. |
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| Workshops : | Chemical synthesis : implication in the research programs of the laboratory of medicinal chemistry ; characterization of the main organic functions and general physicochemical properties of the synthesized compounds.
Place : laboratory for the students, +4 floor, tour 4, Bât. B36. |
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| Organization : | The lessons (1 h 30) are usually given twice weekly during the first semester. |
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| Written notes : | Written notes upgraded each year are distributed to the students. |
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| Assessment : | Written exam in january (first session).
Written exam in august-september (second session). |
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| Contacts : | Professeur Bernard PIROTTE
Laboratoire de Chimie Pharmaceutique
1, Avenue de l'Hôpital, B-4000 Liège
C.H.U. - tour 4 - niveau + 5 (Bât. B36)
tel : 04 366 43 65 - fax : 04 366 43 62
e-mail: B.Pirotte@ulg.ac.be
Secrétariat : Mme Christine SERVAIS (tel : 04 366 43 61) |
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