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| PHAR0355-1 | Complements of drug analysis in complex media
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| Duration : | 10h Th |
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| Credits/ECTS : |
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| Holder(s) : | Patrice Chiap, Jacques Crommen, Marianne Fillet |
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| Language : | Langue française |
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| Course contents : | 1) Preparation of samples for bioanalysis (P. Chiap):
- Review of the importance and the objectives of treatment of biological samples.
- Description of different modes of preparation of biological samples.
- Detailed presentation of the technique for extraction in the solid phase and its automatization (at-line and on-line modes).
- Description of the main types of support for extraction.
2) Mass spectrometry in complex environments (M. Fillet):
- Review of the theoretical ideas involved with mass spectrometry.
- Description of the main sources and analyzers used for the analysis of medicines in complex environments.
- Requirements connected to the presence of complex matrices (preparation of samples, coupling with a separation technique: LC, GC or CE, ionization suppression effect).
- Presentation of LC-, CE- and GC-MS applications.
3) Chirality (A. Ceccato)
4) Practice with chromatographical methods in complex environments (J. Crommen)
5) Validation of bioanalytical methods (P. Chiap):
- Review of the context of validation in bioanalysis.
- Detailed description of the criteria of validation applied in bioanalysis.
- Presentation of a protocol for validation of a bioanalytical method.
- Analysis of guidelines and recommendations of the FDA in this regard. |
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| Course objective : | Compléter la formation des étudiants dans le domaine de l'analyse des médicaments en milieux complexes. |
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| Prerequisites : | 1er année du grade de master en sciences pharmaceutiques (http://progcours.ulg.ac.be/cocoon/programmes/--.html#PHAR0355-1) |
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| Contacts : | jcrommen@ulg.ac.be
p.chiap@ulg.ac.be
marianne.fillet@ulg.ac.be |
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