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| INFO0430-2 | Notions of bioinformatics
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| Duration : | 10h Th, 10h Pr |
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| Credits/ECTS : |
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| Holder(s) : | Olivier Peulen |
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| Language : | Langue française |
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| Course contents : | The course will define and describe stakes of bioinformatics in XXIst century. Genomic and proteomic databases will be described. Retrieving of sequences in databases will be explained. Some algorithms of exon detection will be exposed. Notions of distance, similarity and homology will be introduced. Dot plots, alignment methods, consensus sequence detection and PCR primer design will be introduced.
Content :
- Introduction and scenario
- Informatic tool
- Cell constituants and bioinformatics
- Databases
- Nucleic acids
- Proteins
- Others
- Sequence retrieval
- Difficulties of sequence analysis
- Exon detection
- Internal signals-based
- Nucleotide composition-based
- Distance, similarity and homology : what do they mean ?
- Sequence comparison and analysis
- Dot-plots
- Sequence alignment
- Consensus detection
- Other tools |
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| Course objective : | Students might be able to use basic bioinformatic softwares available on WWW and to understand mechanisms involved in this softwares. This understanding might allow them to determine limitations of each procedure. |
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| Prerequisites : | Basic knowledge of web.
Statistic and Probability |
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| Workshops : | Practical use of bioinformatic web ressources : Genbank, Swissprot, PDB, BLAST, primer3, ... |
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| Organization : | Lessons take place during the 2nd semester of the first master, 2 h/week for 5 weeks. |
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| Written notes : | Syllabus (~100 pages) and a CD with powerpoint files are available. Syllabus can be obtained at Intercopy or on My ULg website. Powerpoint files can be obtained on My ULg website. |
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| Assessment : | Oral examination |
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| Contacts : | Olivier Peulen
Laboratory of Tumor and Development Biology
CHU - Tour de Pathologie B23
Te: 04/366.35.70
E-mail: Olivier.Peulen@ulg.ac.be |
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| Remarks : | Textbook : Introduction to Bioinformatics, Arthur M. Lesk, Oxford University Press (2002) |
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