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| CHIM0652-1 | Molecular recognition and non-covalent interactions
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| Duration : | 15h Th |
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| Credits/ECTS : |
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| Holder(s) : | Valérie Gabelica |
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| Language : | Langue française |
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| Course contents : | - The different types of noncovalent interactions: electrostatic, hydrogen bonding, hydrophobic, van der Waals, stacking interactions...
- Biophysical methods for the study of noncovalent interactions: spectroscopic methods (UV-vis, CD, fluorescence, FRET, NMR), calorimetric methods (ITC, DSC), surface interaction analysis (SPR, AFM). Data exploitation to extract macroscopic thermodynamic parameters.
- Interpretation of macroscopic thermodynamic data in terms of molecular structure and dynamics. Structure-activity relationships.
- Examples of application in biology and pharmacology. |
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| Course objective : | Understand which techniques is best appropriate to a given problem, what are the limitations of the different methods, what are the underlying assumptions in the data interpretation process. |
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| Prerequisites : | Physical chemistry (3rd year) |
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| Organization : | 2nd semester, 7 or 8 lectures and discussion (2h) |
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| Written notes : | Copy of the slides. List of key review/tutorial articles. |
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| Assessment : | Seminar presented by the students: presentation and discussion of a recent article. |
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| Contacts : | Dr. Valérie Gabelica
Mass Spectrometry Laboratory
Institut de Chimie, Bat B6c, Local R65/A
Tel. +32-4-3663432
Fax. +32-4-3663413
e-mail. v.gabelica@ulg.ac.be |
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