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| CHIM0311-5 | Elements of mineral and organic chemistry to drug analysis and drug design
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| Duration : | 40h Th, 25h Pr, 10h QA Sess. |
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| Credits/ECTS : |
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| Holder(s) : | Jean‑François Liégeois |
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| Language : | Langue française |
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| Course contents : | Several sessions will be devoted to general notions related to organic bonds, major reaction types, hydrophilicity and lipophilicity as well as pH impact on such parameters.
Major functional groups (i.e. hydrocarbons, halogenated derivatives, alcohols, amines, acetaldehydes and ketones, acids and derivatives) will be presented. Preparations, physical properties, pH impact on hydro-lipophilic properties and molecule stability, as well as chemical reactivity will be described.
The issue of aromatic compounds and their derivatives will be dealt with from similar angles (preparations, physical properties, chemical reactivity). Aromatic heterocycles will be studied as well.
Most important mineral compounds used in pharmaceutical will be examined (solubility, interaction with pH, oxidative or reductive properties,...). Possible interations with organic compounds will be also detailed. |
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| Course objective : | Knowing about the reactivity and/or stability of organic functions for instance considering chemical agents or pH variation.
Grasping the spatial structure of organic molecules.
Recognizing fragility points in more complex molecules.
Recognizing polar and apolar fragments in organic molecules or even assessing hydrophilic/lipophilic natures.
Knowing about the major synthesis routes of functional groups from the mechanistic angle so as to understand the synthesis of more complex drugs.
Knowing properties of major mineral compounds used in pharmaceutical sciences and their interactions with organic compounds. |
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| Prerequisites : | The structure of common atoms in organic chemistry (C, H, N, S, O, P, B...).
Major organic functions.
Basic mineral reagents and physicochemical characteristics (NaOH, HCl, KMnO4, NA2CO3,...). |
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| Workshops : | Organic chemistry experiments with a view to applying major studied reactions. Compound isolation, purification and analysis.
Extraction and characterization of natural compounds.
Qualitative analysis of organic compound and determination of physicochemical characteristics (solubility and extractability).
Qualitative analysis of mineral compounds and determination of physicochemical characteristics (solubility and extractability). |
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| Organization : | Theoretical course : see vademecum
Repetition sessions: to be determined
Practicals: six sessions, Practical hall level +4 CHU tower 4 (B36) |
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| Written notes : | A copy of PowerPoint presentations and written lecture notes are available |
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| Assessment : | An written evaluation is organised quickly after beginning on matter previously seen during the first year. The written exam on the course is scheduled in January. Important concepts will be defined for improved grade. For the first session, the grade will include the results of the preliminary evaluation (2/20), the results of the practical work (2/20) and those of the examination (16/20). For the second session, only the results of the written examination will be taken into account |
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| Contacts : | Jean-François Liégeois
Associate Professor
Research Director of the Scientific Research National Fund
Department of Pharmacy
Avenue de l'Hôpital, 1 (B36, CHU, Tour 4, niv. +5)
B-4000 Liège 1
Phone: 32 (0)4 366 43 77
Fax: 32 (0)4 366 43 62
Email: JF.Liegeois@ulg.ac.be
Supervision: Practical/Repetition sessions
To be defined |
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| Remarks : | Student assistant: this job is available for those interested by the teaching of mineral and organic chemistry. It corresponds to an assisatnace during practical sessions
Research: after the second year of the formation, students interested by organic chemistry and drug design are welcome for research training under my supervision Application for Research student position is also possible.
Medicinal chemistry training can be done during the last year of the formation.
Finally, PhD degree can be prepared in the research unit. |
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