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| BIOC0204-1 | Biochemistry and thermodynamics of biological systems
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| Duration : | 40h Th, 20h Pr |
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| Credits/ECTS : |
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| Holder(s) : | Moreno Galleni |
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| Language : | Langue française |
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| Course contents : | - Thermodynamic
Free energy and activation energy
Free energy and oxydoreduction potential
Reversibility of the biochemical reaction
chemical potential
Osmose phenomenon
Introduction to the mechanism of diffusion
- Nature of the non covalent interactions between biomolecules
-Organisation levels of proteins
- Enzymes
Co-enzymes, co-factors and co-substrates
Introduction to enzymatic kinetic
Introduction to allosteric mechanism
Example of catalysis: chymotrypsin and the family of active site serine proteolytic enzymes
- Proteins of interest
Myoglobin and hemoglobin
Immunoglobulins
- Carbohydrates and glycoproteins
- Lipids and lipoproteins
-Introduction to bioenergetics
-Carbohydrate catabolism
Glycogenolysis
Glycolysis and its regulation
Destiny of pyruvate in anaerobic conditions
Destiny of pyruvate in aerobic condition
Oxydative phosphorylation
- Gluconeogenesis and its regulation
destiny of carbohydrates in the organism
-Degradation of fatty acids and lipids
-Protein degradation and destiny of amino acids
- Biochimistry of the gene - DNA
DNA composition
Structure of DNA
Gentic information and DNA
DNA organisation in chromosomes
- Dynamic of genes
DNA replication in prokaryotes
DNA replication in eukaryotes
Genetic code
Transcription and messager RNA
- Protein biosynthesis
Transfer RNA or tRNA
Ribosomes
mechanism of protein synthesis
Destiny of proteins
-Control of gentic expression |
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| Course objective : | The lectures will be devoted on :
- physical and chemical basis of biochemistry
- molecular basis of metabolic pathways involved in the regulation of biological process |
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| Prerequisites : | Basic lecture in inorganic and organic chemistry
Courses of general biology |
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| Workshops : | 3 lectures
- kinetic
- Determination od protein concentration
- Dyalisis and molecular sieve
Place: Batiment de chimie (B6 - sart Tilman) pour des travaux pratiques de candidature |
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| Organization : | 20 lecture of 2 hours
3 laboratory sessions
1 exercice session |
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| Written notes : | Overheads and Power Point presentation
Syllabus |
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| Assessment : | Written and oral examination |
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| Contacts : | Lectures:
Galleni Moreno, Local 3/7, Institut de Chimie , B6. Sart Tilman
Phone:04/3663549 - Fax:04/3663364 - Email:mgalleni@ulg.ac.be
Practical lectures:
Dr. Feller Georges, Chef de Travaux
Institut de chimie B6 Sart Tilman
Phone 04/3663343 Fax 04/3663364 email:gfeller@ulg.ac.be
Berlemont Renaud, Assistant
local 1/34, institut de Chimie, B6a. Sart Tilman
Phone: 04/3663348- Fax: 04/3663396 - Email:rberlemont@student.ulg.ac.be |
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