 | |
| CHIM0311-4 | Organic chemistry applied to pharmaceutical sciences
 |
|
| Duration : | 40h Th, 20h Pr, 10h QA Sess. |
|
| Credits/ECTS : |
|
|
| Holder(s) : | Jean‑François Liégeois |
|
| Language : | Langue française |
|
| Course contents : | Several sessions will be devoted to general notions related to organic bonds, major reaction types, hydrophilicity and lipophilicity as well as pH impact on such parameters.
Major functional groups (hydrocarbons, halogenated derivatives, alcohols, amines, acetaldehydes and ketones, acids and derivatives¿) will be presented. Preparations, physical properties, pH impact on hydro-lipophilic properties and molecule stability, as well as chemical reactivity will be described.
The issue of aromatic compounds and their derivatives will be dealt with from similar angles (preparations, physical properties, chemical reactivity). Aromatic heterocycles will be studied as well. |
|
| Course objective : | Knowing about the reactivity and/or stability of organic functions ¿ for instance considering chemical agents or pH variation.
Grasping the spatial structure of organic molecules.
Recognizing fragility points in more complex molecules.
Recognizing polar and apolar fragments in organic molecules or even assessing hydrophilic/lipophilic natures.
Knowing about the major synthesis routes of functional groups from the mechanistic angle so as to understand the synthesis of more complex drugs. |
|
| Prerequisites : | The structure of common atoms in organic chemistry (C, H, N, S, O, P, B...).
Major organic functions.
Basic mineral reagents¿ physicochemical characteristics (NaOH, HCl, KMnO4...). |
|
| Workshops : | Organic chemistry experiments with a view to applying major studied reactions. Compound isolation, purification and analysis.
Extraction and characterization of natural compounds.
Organic compound qualitative analysis and determination of physicochemical characteristics (solubility and extractability). |
|
| Organization : | Theoretical course
Repetition sessions: to be determined
Practicals: five sessions, Practical hall R/14 (B6) |
|
| Written notes : | A copy of PowerPoint presentations and written lecture notes are available. |
|
| Assessment : | ... |
|
| Contacts : | Jean François Liégeois
Deputy Lecturer
FNRS Senior Research Associate (Scientific Research National Fund)
Département de Pharmacie
Avenue de l'Hôpital, 1 (B36, CHU, Tour 4, niv. +5)
B-4000 Liège 1
Phone: 32 (0)4 366 43 77
Fax: 32 (0)4 366 43 62
Email: JF.Liegeois@ulg.ac.be
Supervision: Practical/Repetition sessions
Yannick Borguet
Assistant
Département de Chimie
Chimie macromoléculaire et catalyse organique (CERM)
allée de la Chimie, 3 (B6)
B-4000 Liège 1
Tél. : 32 (0)4 366 35 68
Fax : 32 (0)4 366 34 97
Email : yborguet@ulg.ac.be |
|
| Remarks : | ... |
|
|
| |
