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| BIOC0209-3 | Chemistry of biological macromolecules
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| Duration : | 60h Th, 40h Pr, 4h Vis. Ind. Pl. |
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| Credits/ECTS : |
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| Holder(s) : | Jean‑Marie Frère, Moreno Galleni |
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| Language : | Langue française |
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| Course contents : | 1) Chemical properties of amino acids and of the polypeptide chain
1.1 Nature of the polypeptide chain
1.2 Amino acids
1.3 Detection of aminoacids, peptides and proteins
1.4 Determination of the protein size
1.5 Determination of the aminoacid sequence
1.6 Chemical synthesis of peptides
1.7 Non ribosomal synthesis of peptides
1.8 Post transcription modification of the polypeptide chain
2) Mechanism of protein localization in prokaryotes and eukaryotes
3) Interactions affecting the properties of proteins
3.1 Nature of non covalent interactions
3.2 Intramolecular interactions
4) Conformational properties of proteins
4.1 Secondary and ternary structures of proteins
4.2 Spectroscopic properties od proteins in solution
5) Biophysical properties of soluble and membranar properties
6) Protein-ligand interactions
7) Introduction to enzymatic catalysis |
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| Course objective : | The first part of the course will be devoted to the structural and chemical properties of proteins. The secind part will be a introduction on enzymatic kinetics. |
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| Prerequisites : | Lectures in genral biochemistry
Thermodynamic and classical physic
Organic chemistry |
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| Workshops : | 40 h of practical course
(the details are not yet defined) |
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| Organization : | 30 lessons of 2 hours |
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| Written notes : | Syllabus + power point presentation |
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| Assessment : | Written + oral examination |
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| Contacts : | Galleni Moreno, Local 3/7, Institut de Chimie , B6. Sart Tilman
Tel:04/3663549 - Fax:04/3663364 - Email:mgalleni@ulg.ac.be |
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