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| IMMU0120-2 | Multidisciplinary approach to the blood system | ||||||||
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| Duration : | 5h Th, 1h QA Sess., 9h APP | ||||||||
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| Holder(s) : | Jacques Boniver, Pierre Bonnet, Jean‑Pierre Bourguignon, Vincent Bours, Alain Carlier, Jean‑Olivier Defraigne, Patrick De Mol, Ernst Heinen, Maurice Lamy, Raymond Limet, Michel Moutschen, Jean‑Pierre Schaaps, André Scheen, Vincent Seutin | ||||||||
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| Course contents : | During this module, the student will be presented with the following issues: blood cells (red blood cells, platelets) and the enzymatic cascades of the coagulation and fibrinolysis. Pathological biochemistry and physiology are the main semester 4 disciplines to be used in the resolution of these issues. Other involved disciplines are histology, semiology, and anatomy. Resolution of clinical problem is not here an aim in itself, but rather a good way of addressing basic pathological concepts. Details of the diagnostic, nomenclature and treatment will not be studied. As far as immunology and hematology are concerned, these topics will be studied from a more clinical perspective during the 1st doctorat. | ||||||||
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| Course objective : | This is a list of general objectives to consider during the resolution of these issues: 1) Knowledge of the main mechanisms responsible for the inflammation which sets in because of an infection; 2) Knowledge of the coagulation mechanisms and stages, as well as the natural or therapeutic activation and inhibition mechanisms; 3) Knowledge of the main clinical biology tests used to study the various blood components; 4) Knowledge of blood's respiratory function; 5) Definition of blood-related medical terms; 6) knowledge and definition of the various anemia types; 7) knowledge of the main coagulation disorders Examples of the various aspects in various disciplines Physiological and biochemical issues are addressed in this module from the point of view of the coagulation process and its regulation as well as the interactions between coagulation and inflammation. Some aspects regarding the physiopathology of coagulation are also presented. Finally, the stages of the creation of the heme and the hemoglobin synthesis as well as the associated disorders. The topics of the summary courses are the following: - Heme synthesis and hemoglobin generation ; - Hemoglobin generation disorders; - Thrombosis, embolism, and clot; - Veins, arteries and coagulation; - Liver and coagulation; - DIC and heparin; - Platelet aggregation and receptors, synergic effects; - Thrombus and fibrinolysis; - Endothelium and platelets; - Anti- and pro-thrombotic effects of the endothelium; - Prostaglandins and platelets; - The links between coagulation and inflammation. | ||||||||
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| Prerequisites : | General biochemistry, general physiology, general histology, general embryology, introduction to human anatomy | ||||||||
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| Written notes : | Anatomy:
- ANATOMIE MEDICALE by K.L. Moore, A.F. Dalley, De Boeck Université (in French) - SOBOTTA (2 volumes) - GRAY'S ANATOMY - ATLAS DE POCHE, Fritsch/Kühnel, Flammarion Biochemistry/physiology: - Physiologie humaine, H. Guénard, 3rd edition - Editions Pradel. - Physiologie médicale, W. Ganong. Translation of the 19th US edition by M. Jobin, Editions DeBoeck Université. - Biochimie hmaine, Introduction à la Médecine Interne. G. Hennen, Editions DeBoeck Université. - ATLAS DE POCHE de Physiopathologie, S. Stilbernagl and F. Lang, Editions Médecine Sciences, Flammarion Embryology: - Embryologie humaine: W.J. LARSEN - De BOECK Université, 1996, (available at the CHU library) - Biologie du Développement: R. BEDDINGTON and others. DUNOD 1999 - Embryologie médicale: J. LANGMAN - Ed Masson - Paris - Interesting URLs - http://www.cbc.umn.edu/~mwd/courses.html - http://www.kuhp.kyoto-u.ac.jp/multimed/VE/VE.html#intro - http://embryo.soad.umich.edu/ - http://membres.lycos.fr/jbdemars/embryo/index.html - http://www.apprentoile.u-bordeaux2.fr/Webryo/Default.htm Histology - see the list distributed during semester 3 - The main reference book: HISTOLOGIE HUMAINE by Stevens et Lowe, Ed. De Boecke - 2002 (id 1997). It is available at the CHU library and at the Service d'Histologie humaine. The Human histology course is available at the AREM. | ||||||||
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| Assessment : | 1st and 2nd session:
- Written exam with 1 open question. 3, open short-answer questions, 40 multiple choice questions with general implicit solutions and certainty levels. - Oral integrative exam (control of competencies). All students undergo an examination by a panel of 5 lecturers. Each panel uses a bank of questions (PBL type). The student selects randomly a question, prepares the answer for 45 minutes and is interrogated for 20 minutes. | ||||||||
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| Contacts : | Anatomy:
Alain Botte, prosecteur, 20, rue de Pitteurs, 4020 Liège Telephone: 04/366.51.53 E-mail: Alain.Botte@ulg.ac.be Dr. X. Nelissen, assistant, Telephone: 04/33-66.72.13 P. Bonnet, chargé de cours, Service d'Urologie,C.H.U. B35, 4000 Sart Tilman, Telephone: 04/366.51.53, E-mail: p.bonnet@chu.ulg.ac.be A. Carlier, chargé de cours, Service de Chirurgie maxillo-faciale, et plastique, C.H.U. B35, 4000 Sart Tilman, Secretary: Melle G. Dereyer - Telephone: 04/366.84.76 Human biochemistry and physiology (normal and pathological: Partim: cardiovascular and respiratory Dr.V Dorio, Chargé de cours CHU Sart-Tilman 04/3667594 Embryology: J.P. SCHAAPS, chargé de cours, Chef de Service Associé de Gynécologie-ObstétriqueCHR Citadelle, Bd du 12e de Ligne, 1, 4000 Liège A. MATHIEU, assistante, 04/366.51.96 (or 97) Histology: E. HEINEN, Professeur ordinaire Service d'Histologie Humaine - Institut d'Anatomie 20, rue de Pitteurs - 4020 LIEGE 2nd floor, Secretary: Telephone: 04/366.51.71 Contact the lecturer during the summary courses or make an appointment through the secretary. For miscellaneous queries, practical exercises, students' problems, please contact Mme MELOT - 04/366.24.09 ; M. JOLOIS - 04/366.51.74 or Melle DEFAWEUX-04/366.51.78, during the practical exercises or in their office on the 2nd floor. E-mail: lecturer: eheinen@ulg.ac.be / tutors fmelot@ulg.ac.be, ojolois@ulg.ac.be, valerie.defaweux@ulg.ac.be Immunology: Professeur MOUTSCHEN's office: 04/366.72.41 | ||||||||
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ULg : Students and Studies Administration - Academic Affairs
Contact : Monique Marcourt, direction A.E.E.
Date of data : 27/02/2006
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