 |  |  |  |  |
| | |
||||
| CHIM0086-1 | Molecular recognition and interactions between biological molecules | |||||
| ||||||
| Duration : | 15h Th | |||||
| ||||||
| Credits/ECTS : |
| |||||
| ||||||
| Holder(s) : | Valérie Gabelica | |||||
| ||||||
| ||||||
| Course contents : | - The different types of noncovalent interactions: electrostatic, hydrogen bonding, hydrophobic, van der Waals, stacking interactions... - Biophysical methods for the study of noncovalent interactions: spectroscopic methods (UV-vis, CD, fluorescence, FRET, NMR), calorimetric methods (ITC, DSC), surface interaction analysis (SPR, AFM). Data exploitation to extract macroscopic thermodynamic parameters. - Interpretation of macroscopic thermodynamic data in terms of molecular structure and dynamics. Structure-activity relationships. - Examples of application in biology and pharmacology. | |||||
| ||||||
| Course objective : | Understand which techniques is best appropriate to a given problem, what are the limitations of the different methods, what are the underlying assumptions in the data interpretation process. | |||||
| ||||||
| Prerequisites : | Physical chemistry (3rd year) | |||||
| ||||||
| Organization : | 2nd semester. 12 lectures (1h). 3h seminar presentations. | |||||
| ||||||
| Written notes : | Copy of the slides. List of key review/tutorial articles. | |||||
| ||||||
| Assessment : | Seminar presented by the students: presentation of a recent article. | |||||
| ||||||
| Contacts : | Dr. Valérie Gabelica Mass Spectrometry Laboratory Institut de Chimie, Bat B6c, Local R65/A Tel. +32-4-3663432 Fax. +32-4-3663413 e-mail. v.gabelica@ulg.ac.be | |||||
| ||||||
ULg : Students and Studies Administration - Academic Affairs
Contact : Monique Marcourt, direction A.E.E.
Date of data : 27/02/2006
Developed by SEGI