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| BIOL0350-1 | Pharmaceutical applications of molecular biology | |||||
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| Duration : | 10h Th | |||||
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| Holder(s) : | Jean‑Paul Chapelle, Alain Chariot | |||||
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| Course contents : | The course gives information on the various applications of the techniques of molecular biology in the field of pharmaceutical sciences. After an introduction devoted to a short recall of molecular biology, the first part of the course consists in showing, using examples drawn from the field of the oncology and inflammatory pathologies, how new pharmacological targets are identified and how the drugs intended are developed to rectify a faulty physiological mechanism. The second part of the course exposes the techniques of bio-engineering applied to the preparation of recombining proteins used like bio-drugs (insulin, interferon-a, interleukine-10...). The new therapeutic approaches, such as the genic therapy and the use of the "interfering" ARN, which offer more targeted approach of the treatment, constitute the third part of the course. Lastly, the last part of the course is devoted to the new diagnostic approaches: on the one hand, the PCR and its interest in the diagnosis and the follow-up of leukaemias, on the other hand, the microphone-arrays and their interest to establish a profile of form of genes and to allow a treatment adapted better in particular pathologies. | |||||
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| Course objective : | The objective of the course is to show the part growing which play biotechnologies in the development of new drugs and the development of various tests making it possible to improve the effectiveness of the treatments | |||||
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| Prerequisites : | Human biochemistry, pathological Biochemistry including medical Chemistry, molecular Biology, Pharmacology | |||||
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| Workshops : | Nothing | |||||
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| Organization : | Run given to the 1st six-month period (five meetings of 2h more one visit of the laboratory). | |||||
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| Written notes : | A. Notes of course and copies of the illustrations.
B. Reference work: Biotechnology, 4th ED. J.E. Smith, Cambridge University Near, 2004. | |||||
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| Assessment : | Written examination. | |||||
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| Contacts : | Prof. J.P. CHAPELLE Service de Chimie médicale, TSI +5 CHU B35 Sart Tilman, 4000 Liège Tel : 04/3667684 - Fax 04/3667666 Secrétariat : 04/3668819 - 04/3668822 E-mail : JP.Chapelle@chu.ulg.ac.be | |||||
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ULg : Students and Studies Administration - Academic Affairs
Contact : Monique Marcourt, direction A.E.E.
Date of data : 27/02/2006
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