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| BIOC0120-1 | General biochemistry | ||||||||||||||
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| Duration : | 30h Th, 10h Pr, 5h SEM | ||||||||||||||
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| Holder(s) : | Jean‑Olivier Defraigne | ||||||||||||||
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| Course contents : | The main aim of biochemistry is the complete understanding at the molecular level of all the chemical processes associated with living cells. This is mainly achieved by isolating molecules and understanding their structure and their function. The field of biochemistry is as vast as life itself, as chemical reactions take place wherever life exists. Biochemists study the chemical reactions and changes which take place in micro-organisms, plants, fish, insects, lesser and superior mammals and human beings. Biochemical knowledge of other forms of life is directly relevant to an understanding of the biochemistry of human beings. For example, current theories on the regulation of gene and enzyme activity spring from earlier studies of bread mould and bacteria. Just as in general physiology, general biochemistry demonstrates the integrated unity of living beings. This course is aimed at understanding organism's molecular structure, the notion of metabolic sequences, the rules governing the integration of these sequences, the general basics of cell energy, the source of inter-cellular free energy, and biochemical tissue specialisation. Specific examples will be chosen to introduce the student to human biochemistry. | ||||||||||||||
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| Course objective : | Understanding the main properties of the various molecule types which make up living beings. Understanding, through a general knowledge of the main analytical methods used, the methodological principles of experimenting within biochemistry. Understanding the main features of the relationships between different molecule types and explaining how the structure of a molecule is maintained or how it carries out specialised work. Showing how the unified structure of cells and organisms existing at the morphological level is also found at the molecular level, and demonstrating how this structure determines specific metabolic sequences. Understanding the way in which metabolic sequences are regulated and the role of enzyme activity within these sequences. Understanding the basic rules of thermodynamics and bio-energy in relation to the structure of living beings. Understanding the main routes taken by the metabolism of living beings' molecule types. Demonstrating the influence of a metabolite's changes in concentration or in structure on the integration of an organism's metabolic sequences. Understanding the relationships between clinical medicine and biochemistry, the way they work together and the more promising analytical paths within biochemistry. To prepare for courses in human biochemistry and general physiology. | ||||||||||||||
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| Prerequisites : | First candidature courses in physics, chemistry (notably organic) and biology. | ||||||||||||||
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| Workshops : | This work will be run by department staff and student assistants and will consist of actual experiments. In parallel with the practical work test exercise sessions will be arranged and will consist of test exercises on course material, examples of questions asked and comments on the results of the test exercises. Exercises and question responses can also be found on the internet: http://www.biphygenhum.be | ||||||||||||||
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| Organization : | Ex-cathedra courses, test exercises, practical applied work and seminars. | ||||||||||||||
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| Written notes : | Syllabus : Biochimie - 1er cycle. G Hennen. Editions DUNOD 2001 Site Internet: http://www.biphygenhum.be This work, for which the newest edition is strongly recommended, can be found in several bookshops, and will be supplemented by texts related to slides used during the course. | ||||||||||||||
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| Assessment : | Oral and written exams in January and September. | ||||||||||||||
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| Contacts : | Jean-Olivier Defraigne, Chargé de Cours Bâtiment B35, CHU Sart-Tilman, B-4000 Liège Tél. 04 366 71 63 Fax 04 366 7164 email : JO.Defraigne @ulg.ac.be Secretary : Mme Amormino (tél. 04 366 7163) | ||||||||||||||
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ULg : Students and Studies Administration - Academic Affairs
Contact : Monique Marcourt, direction A.E.E.
Date of data : 27/02/2006
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